the cd4+/cd8+ ratio in pulmonary tuberculosis: systematic and meta-analysis article.
نویسندگان
چکیده
the ratio of cd4+/cd8+ has been used as a clinically index to evaluate patients' immunity. numerous researchers have studied cd4+/cd8+ ratio in pulmonary tuberculosis (ptb) patients. however, the change of cd4+/cd8+ ratio remains controversial. we present a meta-analysis of 15 case-control studies to identify the change of cd4+/cd8+ ratio in ptb patients.we assessed heterogeneity of effect estimates within each group using i(2) test. subgroup analysis was performed to explore the potential source of heterogeneity. to investigate further the potential publication bias, we visually examined the funnel plots. for robustness of results, we performed sensitivity analysis by removing studies. data entry and analyses were carried out with revman 5.2 (the nordic cochrane centre).twelve peripheral blood studies were categorized into two subgroups. eight studies presented a significant decrease of cd4+/cd8+ ratio in ptb cases compared to healthy subjects (smd: -0.45; 95% ci -0.65--0.25; i(2) = 7%). other four studies researched on the newly diagnosed patients presented a more seriously and significantly decrease (smd: -2.17; 95% ci -2.61--1.74; i(2) = 37%). the pooled analysis of bronchoalveolar lavage fluid (balf) studies showed a significant increase of cd4+/cd8+ ratio using flow cytometry (fcm) (smd: 4.75; 95% ci 3.44-6.05; i(2) =0%).the present meta-analysis indicated that there was a synthetic evidence for the reduced cd4+/cd8+ ratio in peripheral blood of ptb patients, especially newly diagnosed cases. however, the cd4+/cd8+ ratio in balf was increased using method of fcm.
منابع مشابه
The CD4+/CD8+ Ratio in Pulmonary Tuberculosis: Systematic and Meta-Analysis Article
BACKGROUND The ratio of CD4+/CD8+ has been used as a clinically index to evaluate patients' immunity. Numerous researchers have studied CD4+/CD8+ ratio in pulmonary tuberculosis (PTB) patients. However, the change of CD4+/CD8+ ratio remains controversial. We present a meta-analysis of 15 case-control studies to identify the change of CD4+/CD8+ ratio in PTB patients. METHODS We assessed hetero...
متن کاملthe stady and analysis of rice agroclimatology in lenjan
the west of esfahan province, iran, is one of the most important agricultural areas throughout the country due to the climate variability and life-giving water of zayanderood river. rice is one of the major and economic crops in this area. the most important climatic elements in agricultural activities which should be considered include temperature, relative humidity, precipitation and wind. so...
15 صفحه اولthe analysis of the role of the speech acts theory in translating and dubbing hollywood films
از محوری ترین اثراتی که یک فیلم سینمایی ایجاد می کند دیالوگ هایی است که هنرپیش گان فیلم میگویند. به زعم یک فیلم ساز, یک شیوه متأثر نمودن مخاطب از اثر منظوره نیروی گفتارهای گوینده, مثل نیروی عاطفی, ترس آور, غم انگیز, هیجان انگیز و غیره, است. این مطالعه به بررسی این مسأله مبادرت کرده است که آیا نیروی فراگفتاری هنرپیش گان به مثابه ی اعمال گفتاری در پنج فیلم هالیوودی در نسخه های دوبله شده باز تولید...
15 صفحه اولInterferon-gamma release assays and childhood tuberculosis: systematic review and meta-analysis [Review article].
BACKGROUND Children infected with Mycobacterium tuberculosis have significant risk of developing tuberculosis (TB) and can therefore benefit from preventive therapy. OBJECTIVE To assess the value of interferon-gamma release assays (IGRAs) and the tuberculin skin test (TST) in the diagnosis of TB infection and disease in children. METHODS Thirty-three studies were included, assessing commerc...
متن کاملTransient Ischemic Dilatation Ratio in Stress Myocardial Perfusion SPECT in Diabetic Patients-A Systematic Review and Meta-Analysis
Abstract Objective: Abnormal values of the transient ischemic dilation (TID) ratio are associated with severe and extensive coronary artery disease (CAD). TID can be used as a diagnostic and prognostic marker of CAD in diabetic patients. The aim of current study was to determine the pooled estimate of TID ratio in single myocardial perfusion scan in diabetic patients by a systematic review and...
متن کاملprevalence and cause of self-medication in iran: a systematic review and meta-analysis article
background: nowadays self-medication is one of the most common public health issues in many countries, as well as in iran. according to need to epidemiological information about self-medication, the aim of this study was to systematic review and meta-analysis of prevalence and cause of self-medication in community setting of iran. methods: required data were collected searching following
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
iranian journal of public healthجلد ۴۴، شماره ۲، صفحات ۱۸۵-۹۳
کلمات کلیدی
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023